Others: molluscum contagiosum, trauma. Treatment Multiple therapeutic strategies have been tried over the years for the management of TSPK, but none of them have resulted to be entirely successful. Antibiotics have not been effective so far. While mild improvements have been reported with trifluridine therapy,  idoxuridine has been shown to cause persistent subepithelial ghost opacities and scarring, and is therefore contraindicated for TSPK.
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Click on the image to see a larger version. Selected References These references are in PubMed. This may not be the complete list of references from this article. Superficial punctate keratitis. J Am Med Assoc. Superficial punctate keratitis; isolation of a virus. AMA Arch Ophthalmol. Trans Ophthalmol Soc U K. Clinical and laboratory observations on superficial punctate keratitis. Am J Ophthalmol. Bull Soc Ophtalmol Fr. Viral isolate in superficial punctate keratitis.
Arch Ophthalmol. Keratitis superficialis punctata Thygeson. Klin Monbl Augenheilkd. Serotyping for homotransplantation. Refinement of microdroplet lymphocyte cytotoxicity test. Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants. Varicella dendritic keratitis.
Latent herpes simplex virus. Isolation from rabbit trigeminal ganglia between episodes of recurrent ocular infection. Isolation of latent herpes simplex virus from the superior cervical and vagus ganglions of human beings. N Engl J Med. Infections due to adenovirus type 8 in the United States. Adenovirus type 8 keratoconjunctivitis in the United States. Epidemiologic, clinical, and microbiologic features.
Adenovirus type 8 infections in the United States. Observations on the pathogenesis of lesions in severe eye disease. Clinical and laboratory evaluation of epidemic keratoconjunctivitis due to adenovirus types 8 and Chronic adenovirus type 2 keratitis in man.
Epidemic keratoconjunctivitis and chronic papillary conjunctivitis in London due to adenovirus type Br J Ophthalmol. Chronic keratoconjunctivitis associated with ocular adenovirus infection.
Studied by light and electron microscopy. The HLA system in human pathology. Pathobiol Annu. Regulation of the immune response by the major histocompatibility system. Scand J Gastroenterol. Specific B-cell antigens associated with gluten-sensitive enteropathy and dermatitis herpetiformis. HLA antigens in dermatitis herpetiformis and coeliac disease.
Tissue Antigens. Transplant Rev.
Thygeson´s superficial punctate keratitis
A viral aetiology has been suggested by the absence of bacterial infection and clinical resemblance to other viral keratopathies. We report the results of polymerase chain reaction analysis for the detection of herpes simplex virus HSV 1 and 2, herpes zoster virus, varicella zoster virus VZV and adenovirus from corneal epithelial samples from patients with active signs and symptoms of TSPK. Methods Schirmer strip impressions were taken from the epithelium of eight patients with a known history of TSPK and symptoms and signs of active disease. Three patients were recruited as positive controls two with herpes simplex keratitis and one with herpes zoster ophthalmicus. Samples from a further three patients acted as negative controls. The three negative control samples showed no evidence of viral DNA. These results are considered in light of existing theories regarding the aetiology and treatment of this condition.
Thygeson's superficial punctate keratitis: natural history and association with HLA DR3.